Bleed is defined as removal of cell culture broth from a perfusion bioreactor to maintain the biomass constant. If this is crucial to stabilize the process, it leads—by definition—to significant protein loss. In this webcast learn about a strategy that uses acoustic wave separation to concentrate the waste stream and recycle the liquid fraction and product of interest back to the bioreactor. While the overall process is not impacted, more of the liquid fraction is removed via the harvest line instead of the bleed.
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